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.. BioMarin Pharmaceutical receives FDA orphan medication designation for 3,4-DAP BioMarin Pharmaceutical Inc. announced today that the meals and Medication Administration offers granted orphan medication designation for 3,4-diaminopyridine , amifampridine phosphate, for the uncommon autoimmune disease Lambert Eaton Myasthenic Syndrome . 3,4-DAP provides received orphan medication designation in the E previously.U. Also, in 2009 October, the Committee for Medicinal Items for Human Usage of the European Medications Evaluations Agency followed a positive opinion recommending acceptance of amifampridine phosphate for LEMS. If accepted by the European Commission, amifampridine phosphate will be the first accepted treatment for LEMS, thereby conferring orphan medication protection and providing a decade of marketplace exclusivity in Europe.